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KMID : 0363620090300060035
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Journal of Korean Oriental Medicine
2009 Volume.30 No. 6 p.35 ~ p.43
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Preventive Effect of Hwangryunhaedok-tang on Inflammatory Responses in PHA-stimulated Peripheral Blood Mononuclear Cells from Cerebral Infarction Patients
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Kim Yun-Ha
Cho Kwang-Ho
Shin Sun-Ho
Lee In
Kim Eun-Sook
Youn Myung-Ja
Kim Jin-Kyung
Moon Byung-Soon
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Abstract
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Objectives: Hwangryunhaedok-tang (HRHDT), a prescription composed of four herbs, has been wi dely used in
Oriental Medicine for the treatment of cerebral infarction. However, the mechanisms by which the herbal formula affects on the production of pro- and anti-inflammatory cytokines in cerebral infarction patients remain unknown yet.
Methods: The levels of pro- and anti-inflammatory cytokines, including tumor necrosis factor (TNF)-a, interleukin
(IL)-1b, and IL-6, IL-10, and TGF-β1 were determined in peripheral blood mononuclear cells (PBMCs) from cerebral infarction patients under our experimental conditions.
Results: The secretory levels of pro- and anti-inflammatory cytokines, including tumor necrosis factor (TNF)-a,
interleukin (IL)-1b, and IL-6, and IL-10 were significantly increased in phytohemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMCs) from cerebral infarction patients. However, pretreatment with HRHDT significantly inhibited the secretion of pro- and anti-inflammatory in PBMCs. Also, HRHDT induced a significant increase of transforming growth factor (TGF)-b1 in PBMCs.
Conclusions: These data indicate that HRHDT may be beneficial in the suppression of inflammatory processes of
cerebral infarct through suppression of TNF-α, IL-1β, IL-6, and IL-10 and induction of TGF-β1.
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KEYWORD
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Hwangryunhaedok-tang (HRHDT), cerebral infarction, pro-inflammatory cytokines, IL-10, TGF-β1
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